Initial Ideas

From FreeBio

{Note: See the Kick-Off Ideas page for the products of brainstorming from our first intro meeting.}


Biofilm, exposed to image, bacteria that responds to UV light. Etch-a-Sketch. More dynamic to. Challenge of genetic system. Transcribe for an hour. Phosphorylation.

Aim to start one thing new, and do one advancing. Modularity using. Other stripes. Tag, tracking. Bacteria. Gradiant. Worms.



Tag

Motile e. coli and non-motile e. coli. Does it copy the plasmid? Cell surface receptor. Notch signaling. Ways of making GFP degrade faster. Make it seem like the other cells are running away. Division of cell.

Temperature Sensor. Looking for more single cell ideas. Temperature sensors. 4 different cell types. Protein. Threshold levels. Sensitivities, some kind. Modularity of

Princeton project (cool). Directed selection.

Apply heat to one part.


Combining different stimulus.

Search DNA computation. Encode each problem as a part of the DNA and have the search find the answer. At each step run the gels.


Input/output Temperature. Moving. Kill themselves.

Turning on Resistance Checking for resistance with light. Cell Density counting Cell adhesion molecules. Checkers. Release a really unstable chemical. Make lots of molecules. Amount of florescence. Measure how many are that close. Reaction diffusion.



Password. A series of stimulus that changes state and expresses only at the goal state. FSA machine.

(password cracker. Tries many combination in parellel)


Diagnostic Cell Blood sample from patient. Detect marker for disease. Related: give it a guess. Ester. Heavy metals in water. Peanuts. Alcohol. Various chemicals. Reduce number of cells. Selecting for.


Wire Passing along signal . Spirals, refactory period. Mollusks.

Polarized cell. Alpha-Factor with yeast. Use these to send a signal. Bud does not grow in a particular spot. Direction specific. Apical and baso-lateral localization.


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References

  • Breaking DES using a molecular computer. by D. Boneh, C. Dunworth, and R. Lipton. In Proceedings of DIMACS workshop on DNA computing, 1995. published by the AMS. link
  • Yaakov Benenson, Binyamin Gil ,Uri Ben-Dor, Rivka Adar & Ehud Shapiro, (2004), An autonomous molecular computer for logical control of gene expression, Nature, 429, 423-429 (published online on April 28, 2004) pdf
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